|
Osteocalcin |
|||||||||||||||||||||||||||||||||
![]() |
PRODUCTS | ORDERING | SERVICES | ABOUT US | FAQ/TECH NOTES | CONTACT | |||||||||||||||||||||||||||
|
Human Proteins Bovine Proteins Mouse Proteins Other Species Inhibitors Substrates Antibodies Sample Collection Tubes Assay Kits Deficient Plasmas Pricing |
|||||||||||||||||||||||||||||||||
|
57 River Road Essex Junction, VT USA Tel: 802.878.1777 Fax: 802.878.1776 Email: hti@haemtech.com |
Osteocalcin, also known as Bone-Gla-Protein (BGP), is a single chain (Mr=5800) vitamin K dependent protein produced by osteoblasts and found in high concentrations in bone (1-4). Post-translational modification by a vitamin K dependent carboxylase produces three g-carboxyglutamic acid residues at positions 17, 21 and 24. The mature protein contains 49 amino acids and a single intrachain disulfide bond joining Cys23 to Cys29. The secondary structure is highly calcium dependent and contains 14% α-helix, 20% β-sheet and 67% random form in the presence of calcium, and 1% α-helix, 20% β-sheet and 79% random form in the absence of calcium (4). BGP binds to phospholipid vesicles in the presence of calcium ions (Kd=6 x 10-6 M) (5). BGP also binds hydroxyapatite and is an efficient inhibitor of hydroxyapatite seeded crystal growth, suggesting a regulatory role in bone mineralization (6). Although the fundamental role of BGP in vivo remains elusive, in vitro experimentation suggests roles in both bone resorption and bone formation. BGP has been shown to function as a chemo-attractant in an in vitro macrophage mediated bone resorption system. The serum concentration of BGP has been linked to bone formation rates, and BGP levels are currently used in research assessment of osteoporosis and other metabolic bone disease states (7). Properties of Osteocalcin
References 1. Price, P.A., et al., in Bone and Mineral Research, Vol. 1, ed. Peck, W., pp. 157-190, Ansterdam: Escerpta Medica (1983).
|
||||||||||||||||||||||||||||||||
|
Please inquire about products not listed. We can also custom purify proteins from other species. |
|||||||||||||||||||||||||||||||||
| © 2004 Haematologic Technologies, Inc. All Rights Reserved | |||||||||||||||||||||||||||||||||